Structural Insights into Ail-Mediated Adhesion in Yersinia pestis
نویسندگان
چکیده
منابع مشابه
Yersinia pestis Ail: multiple roles of a single protein
Yersinia pestis is one of the most virulent bacteria identified. It is the causative agent of plague-a systemic disease that has claimed millions of human lives throughout history. Y. pestis survival in insect and mammalian host species requires fine-tuning to sense and respond to varying environmental cues. Multiple Y. pestis attributes participate in this process and contribute to its pathoge...
متن کاملResistance of Yersinia pestis to complement-dependent killing is mediated by the Ail outer membrane protein.
Yersinia pestis, the causative agent of plague, must survive in blood in order to cause disease and to be transmitted from host to host by fleas. Members of the Ail/Lom family of outer membrane proteins provide protection from complement-dependent killing for a number of pathogenic bacteria. The Y. pestis KIM genome is predicted to encode four Ail/Lom family proteins. Y. pestis mutants specific...
متن کاملInsights into the evolution of Yersinia pestis through whole-genome comparison with Yersinia pseudotuberculosis.
Yersinia pestis, the causative agent of plague, is a highly uniform clone that diverged recently from the enteric pathogen Yersinia pseudotuberculosis. Despite their close genetic relationship, they differ radically in their pathogenicity and transmission. Here, we report the complete genomic sequence of Y. pseudotuberculosis IP32953 and its use for detailed genome comparisons with available Y....
متن کاملAil Proteins of Yersinia pestis and Y. pseudotuberculosis Have Different Cell Binding and Invasion Activities
The Yersinia pestis adhesin Ail mediates host cell binding and facilitates delivery of cytotoxic Yop proteins. Ail from Y. pestis and Y. pseudotuberculosis is identical except for one or two amino acids at positions 43 and 126 depending on the Y. pseudotuberculosis strain. Ail from Y. pseudotuberculosis strain YPIII has been reported to lack host cell binding ability, thus we sought to determin...
متن کاملNew Insights into How Yersinia pestis Adapts to Its Mammalian Host during Bubonic Plague
Bubonic plague (a fatal, flea-transmitted disease) remains an international public health concern. Although our understanding of the pathogenesis of bubonic plague has improved significantly over the last few decades, researchers have still not been able to define the complete set of Y. pestis genes needed for disease or to characterize the mechanisms that enable infection. Here, we generated a...
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ژورنال
عنوان ژورنال: Structure
سال: 2011
ISSN: 0969-2126
DOI: 10.1016/j.str.2011.08.010